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The effect of DAX-1 and its mutants on SF-1/Egr-1 synergistic activation of the rat LHβ gene promoter. Cotransfection of human SF1 (FTZF1) (20 ng) with rat Egr1 (20 ng) produced synergistic activation of the rat LHβ gene promoter (–154 to +5) (500 ng). Repression by wild-type (WT) DAX-1 (50 ng) was reduced when the R267P, ΔV269, and Δ448–470 DAX-1 mutant vectors were investigated. The I439S mutant had intermediate function.
