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. 2000 Feb 1;105(3):301–310. doi: 10.1172/JCI7358

Figure 1.

Figure 1

(a) Anti-Gal IgG production in α1,3GT KO mice immunized 3 times with kidney membranes from pig (filled circles) or C3H mouse (open circles). Data represent anti-Gal activity in 3 characteristic mice of 8 in each group with similar results. (b) Anti-Gal IgG activity in 5 mice immunized first 3 times with WT mouse kidney membranes followed by 3 immunizations with pig kidney membranes. Data represent absorbance 2 weeks after each immunization at serum dilution of 1:100. (c) Anti-Gal IgM response in nonimmunized α1,3GT KO mice (open squares), mice immunized 3 times with pig kidney membranes (filled circles), or with WT mouse kidney membranes (open circles). Data from 2 representative mice from groups of 5 animals per group. (d) Anti-Gal IgM (filled circles) and IgG (open circles) response in mice immunized 3 times with glycolipids containing α-gal epitopes in amounts equivalent to the amount of this epitope in 100 mg pig kidney membranes. Data are from 3 representative mice of 6 per group with similar results.