Figure 3.

Allogeneic response of α1,3GT KO mice to C3H mice. (a) Stimulation of lymphocytes from 5 α1,3GT KO mice in a MLR with irradiated C3H mouse lymphocytes as stimulatory cells (closed columns) or in the absence of stimulatory cells (open columns). (b) Production of alloantibodies in α1,3GT KO mice immunized with C3H kidney membranes; FACS analysis of C3H spleen lymphocytes incubated with sera from nonimmunized α1,3GT KO mice (broken line), or sera from immunized mice (solid line). The left peak in each histogram represents T cells, whereas the right peak represents B cells. Data are from 1 of 5 mice with similar results.