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. 2000 Feb 1;105(3):301–310. doi: 10.1172/JCI7358

Figure 5.

Figure 5

Effect of α-gal epitope expression on in vitro proliferation of spleen lymphocytes from nonimmunized α1,3GT KO mice (open columns) or from α1,3GT KO mice immunized 3 times with pig kidney membranes (closed columns). Pig kidney membranes or pig PK15 cells were treated with α-galactosidase for the removal of α-gal epitopes. COS α GT and BL6 α GT cells are transfected with mouse α1,3GT cDNA and express α-gal epitopes. Glycolipids extracted from rabbit RBC were assayed at concentrations that corresponded to α-gal epitope expression by 100 μg/mL of pig kidney membranes. Data are mean ± SE of from 5 mice in each group.