FIGURE 1.

RUNX2 positively correlates with proliferation in osteosarcoma. A, tissue biopsies obtained from normal bone and primary osteosarcoma were stained for RUNX2 and proliferation marker Ki-67. B, samples were scored for staining intensities and grouped in categories with no or very low staining, medium staining, and high staining. High or medium expression of RUNX2 correlates with expression of Ki-67 in 13 of 23 samples, suggesting a loss of the reciprocal relationship between RUNX2 and cell proliferation. Scale bar, 50 μm.