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The p53/miR-34/Runx2 circuit. A, expression analysis of miR-34c in normal human bone and OS biopsies by qRT-PCR revealed significant down-regulation of miR-34c in OS compared with normal bone tissue. Values are presented as relative to U6 expression. End products of the qRT-PCR reaction were separated in 3.5% agarose gel. B, shown is a schematic of the proposed model of the p53/miR-34/Runx2 regulatory circuit.
