Table 1.

The circadian rhythm in blood pressure in circadian clock mutant mice

Mouse Mutant	Light Cycle	Mean Arterial Blood Pressure, mmHg
		Mutant		WT
		Night	Day	Night	Day
Cry1-Cry2-DKO (90)	DD	90	92	86	80
Bmal1-KO (17)	LD	97	95	115	105
Npas2-mut (17)	LD (DD)	104	92	110	98
Clock mut (17)	LD	∼102	∼96	110	98
Clock mut (Jcl/Icr) (120)	LD	∼130	∼115	∼130	∼105
Per2 mut (142)	LD	105.9±1.9		116.5±2.1

Four distinct studies have examined blood pressure in mice with mutated circadian clocks (citations shown in parentheses). Shown are the average mean arterial pressures at night and day. Studies in Per2 mutant (mut) mice are single time point studies, but the hypotensive phenotype that was observed in all circadian clock mutant mice except for the Cry1-Cry2 double knockout (DKO) mice was still observed. Values for Clock mut mice were approximated from bar graphs in accompanying studies. WT, wild type; DD, constant darkness condition; LD, light-dark condition; KO, knockout.