Figure 8.

Fat transplantation increases serum leptin and improves insulin levels in a dose-dependent way. A-ZIP/F-1 mice (n = 5–7/group) were transplanted with 100, 300, or 900 mg of parametrial fat. (a) Serum leptin levels were measured 13 weeks after transplantation, with serum from ob/ob mice indicating the assay background. Leptin levels in the 900- and 300-mg groups were significantly different from the sham group. (b) Serum insulin, triglyceride, and FFA levels were measured at the indicated times in the sham-operated (filled circles), 100-mg (open circles), 300-mg (filled triangles), and 900-mg (open triangles) transplanted A-ZIP/F-1 mice and in wild-type controls (filled squares).