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. 2012 Feb 3;302(10):L977–L991. doi: 10.1152/ajplung.00362.2011

Table 1.

Pulmonary hypertension and pulmonary vasculature remodeling in mouse models published from 1996 to 2011

RVSP, mmHg
 RV/LV+S
 Histology
Mouse Strain Genetic Modification Normoxia Hypoxia Normoxia Hypoxia Normoxia Hypoxia Author
C57BL6/J Wild type/Normal 13 18 N/A N/A N/A ↑ musc. Vanderpool et al. (108)
C57BL6/J Wild type/Normal 10–20 14–26 0.24 0.31 N/A N/A Tabima et al. (98)
C57BL6/J 5-LO KO N/A N/A 0.25 0.32 Normal ↓ musc. Voelkel et al. (112)
C57BL6/J PGI2 synthase OE 30 30 N/A N/A Normal ↓ musc. Geraci et al. (33)
C57BL6/J HO-1 KO 12 19 N/A N/A N/A modest musc. Yu et al. (129)
FVB/N SMC BMPR2 dom. neg 44 N/A 0.315 N/A ↑ musc. N/A West et al. (116)
C57BL6/J BMPR2± 12 N/A N/A N/A N/A N/A Song et al. (91)
BMPR2± with Ad5LO OE 23 N/A N/A N/A N/A ↑ musc.
C57BL6/J 5-HTT OE 33 N/A 0.37 N/A ↑ musc. N/A Guignabert et al. (39)
C57BL6/J VIP KO 29.5 N/A 0.34 N/A ↑ musc. ↑ musc. Said et al. (80)
R26R PVEC BMPR−/− KO 27 N/A 0.27 N/A ↑ musc. Occlusion N/A Hong et al. (42)
C57BL6/J SMC PPAR-γ −/− KO 29 N/A 0.45 N/A ↑ musc. N/A Hansmann et al. (40)
C57BL6/J SMC BMPR2± 24 N/A N/A N/A ↑ musc. N/A Song et al. (90)
SMC BMPR2± with MCT + Ad5LO 38 N/A N/A N/A ↑ musc. Inflamm. N/A
C57BL/6 Eln−/− 80 N/A ↑ RV hyp. N/A ↑ musc. N/A Shifren et al. (86)
FVB/N SMC BMPR2 R899X 39 N/A N/A N/A ↑ musc. N/A West et al. (117)
C57BL/6 Wildtype with OVA exposure 25 32 0.20 N/A ↑↑↑ musc. ↑↑↑ musc. Daley et al. (19)
C57BL6/J TPH1 −/− KO with dexfenflur. 15 N/A 0.23 N/A Normal N/A Dempsie et al. (20)
HumanSERT+ with dexfenflur 40 24 0.27 0.30 ↑ musc. ↑ musc.
Wild type with dexfenflur 30 N/A 0.21 N/A ↑ musc. N/A
C57BL6/J Notch −/− KO 20 20 0.20 0.22 N/A ↑ musc. Li et al. (56)
C57BL6/J IL-6 OE 35 63 0.36 0.69 N/A ↑ musc. Occlusion Inflamm. Steiner et al. (94)
C57BL6/J SMC ID-1−/− KO 20 28 0.258 0.36 Normal ↑ musc. Lowery et al. (57)
C57BL6/J Nogo−/− 15* 15* 0.16 0.23 N/A ↓ musc. Sutendra et al. (96)
C57BL6/J A2AR−/− 39 45 0.26 N/A ↑ musc. N/A Xu et al. (122)
C57BL6/J Wild type with imatinib 23 25 0.29 0.34 ↓ musc. Gambaryan et al. (31)
    N/A CTGF OE 22 N/A 0.42 ↑ musc. N/A Chen et al. (15)
C57BL6/J HumanMMP9 OE 29 N/A N/A N/A N/A N/A George et al. (32)
HumanMMP9 OE with MCT 90 N/A N/A N/A ↑ musc. Inflamm N/A
C57BL6/J RKIP −/− 25 35 0.28 0.35 N/A N/A Morecroft et al. (66)
FVB/N SMC BMPR2 R899X 43 N/A 0.34 N/A ↑ musc. N/A Yasuda et al. (124)
SMC BMPR2 R899X with fasudil 37 N/A 0.28 N/A ↓ musc. N/A
C57BL6/J COX-2 −/− KO 13 N/A N/A N/A N/A N/A Seta et al. (85)
COX-2 −/− KO with MCT 17 N/A N/A N/A Perivascular edema N/A
FVB HumanHO-1 OE 20 21 0.21 0.22 Normal ↓ musc. Vergadi et al. (109)
SV129 Apelin KO 25 33 N/A N/A N/A ↑ musc. Chandra et al. (14)
C57BL6/J Wild type/Normal 22 35 0.20 0.45 N/A ↑ musc. Yu et al. (130)
C57BL6/J P53 KO 18 35 0.21 0.35 Normal ↑ musc. Mizuno et al. (64)
C57BL6/J Wild type/Normal with SU5416 27 50 0.20 0.35 Normal ↑ musc. occlusion Ciuclan et al. (16)
R26R PVEC BMPR−/− KO 37 N/A 0.23 N/A ↑ musc. N/A Burton et al. (13)
PVEC BMPR−/− KO with SCH527123 26 N/A 0.19 N/A ↓ musc. N/A
CD1-B6.Cg 5Amc/J Calpain-4 KO 18 21 0.19 0.20 Normal ↓ musc. Ma et al. (58)
C57BL6 OX40L OE 30 N/A 0.23 N/A ↑ musc of large vessels N/A Rabieyousefi et al. (74)
C57BL6 S. Mansoni parasitic infection 31 N/A 0.25 N/A ↑ musc. N/A Crosby et al. (18)

RVSP, right ventricular systolic pressure; RV, right ventricle; LV, left ventricle; S, interventricular septum; N/A, not analyzed; KO, knockout; OE, overexpression; SMC, smooth muscle cell; PVEC, pulmonary vascular endothelial cell; 5-LO, 5-lipoxygenase; PGI2, prostacyclin; HO, heme oxygenase; BMPR2, bone morphogenetic protein receptor type 2; Ad5LO, adenoviral vector overexpressing 5-lipoxygenase; 5-HTT, 5-hydroxytryptamine transporter; VIP, vasoactive intestinal peptide; PPAR, peroxisome proliferator-activated receptor; MCT, monocrotaline; Eln, elastin; OVA, ovalbumin; TPH1, tryptophan hydroxylase-1; dexfenflur, dexfenfluramine; SERT, human serotonin receptor; IL-6, interleukin 6; ID-1, inhibitors of differentiation; A2aR, adenosine A2 receptor; CTGF, connective tissue growth factor; MMP, matrix metalloproteinase-9; RKIP, Raf-1 kinase inhibitor protein; COX-2, cyclooxygenase 2.

*

, mean pulmonary artery pressure.