Table 1.
CON | BLK | |
---|---|---|
HR, beats/min | ||
Baseline | 65 ± 4 | 62 ± 5 |
Max | 79 ± 5 | 72 ± 4 |
SV, ml/beat | ||
Baseline | 98 ± 7 | 84 ± 7 |
Max | 115 ± 9* | 93 ± 7 |
CO, l/min | ||
Baseline | 6.3 ± 0.6 | 5.1 ± 0.4† |
Max | 8.4 ± 0.9* | 6.2 ± 0.5*† |
MAP, mmHg | ||
Baseline | 122 ± 3 | 116 ± 4 |
Max | 110 ± 3* | 107 ± 4 |
MVP, mmHg | ||
Baseline | 20 ± 1 | 20 ± 1 |
Max | 22 ± 2* | 22 ± 1* |
LBF, ml/min | ||
Baseline | 457 ± 59 | 446 ± 44 |
Max | 1,756 ± 251* | 1,364 ± 168* |
LVC, ml·min−1·mmHg−1 | ||
Baseline | 3.7 ± 0.4 | 4 ± 0.7 |
Max | 15.4 ± 2.0* | 12.8 ± 1.7* |
Values are means ± SE. CON, control; BLK, fentanyl blocking; HR, heart rate; SV, stroke volume; CO, cardiac output; MAP, mean arterial pressure; MVP, mean leg venous pressure; LBF, leg blood flow; LVC, leg vascular conductance. Note that these data represent peak values on an individual basis, and for this reason they do not match the average responses illustrated in Figs. 1 and 2.
Difference from baseline,
difference from CON: P < 0.05. As the main effect of time for HR, SV, and MAP were not significant in BLK, the significance of the change from baseline to maximum was not determined.