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. 2009 Nov 25;298(2):G275–G282. doi: 10.1152/ajpgi.00344.2009

Fig. 6.

Fig. 6.

Inhibition of NF-κB reverses TGF-β-induced downregulation of PTEN promoter activity in BxPc-3 cells. Cells were transfected with PTEN-luc construct together with an empty vector (MT-vector) or the dominant negative mutant IκB-αM for 24 h. They were then treated with TGF-β for 24 h and subjected to luciferase assay. TGF-β downregulates PTEN promoter activity but dominant negative mutant IκB-αM completely reversed downregulation of PTEN promoter activity. ***P < 0.001 vs. Control; +++P < 0.001 vs. TGF-β. Data were means ± SE of 6 samples.