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. 2012 Nov 30;304(3):H415–H426. doi: 10.1152/ajpheart.00468.2012

Fig. 1.

Fig. 1.

Extracellular nicotinamide phosphoribosyltransferase (eNampt) is prohypertrophic in vivo. A: cardiac Nampt levels in the nontransgenic (N-Tg) control and in the Nampt-Tg mice. B: heart weight (HW)-to-body weight (BW) ratio of control and Nampt-Tg mice. C: sections of hearts treated with Masson's trichrome to detect fibrosis (blue). D: quantification of cardiac fibrosis in control and Nampt-Tg mice. E and F: echocardiographic measurements of left ventricular fractional shortening and wall thickness of control and Nampt-Tg hearts. G: β-myosin heavy chain (β-MHC), collagen-1 (Col1a1), and α-smooth muscle actin (α-SMA) mRNA levels in the heart samples of control and Nampt-Tg mice. H: representative heart sections of control and Nampt-Tg mice showing CD31 staining. I: quantification of relative capillary density in 2 groups of hearts. Means ± SD; n = 5–7.