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. 2000 Feb 1;105(3):261–270. doi: 10.1172/JCI8856

Figure 4.

Figure 4

Yolk sac vascular defects in dHAND-null embryos. Unlike wild-type yolk sacs at E9.5 (a), dHAND-null yolk sacs at E9.5 display absence of visible vessels (b). Expression of lacZ under control of the Tie2 promoter in wild-type (c) and mutant (d) yolk sacs revealed a honeycomb-like vascular plexus in dHAND-mutants rather than the remodeled vessels present in the wild-type (e) and (f) represent histologic sections of c and d, respectively. Arrowheads indicate vessels; arrows indicate endothelial cells.