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Glagov remodeling does not occur in some mouse plaques. The minimum bounding circle circumscribed around the external elastic lamina (yellow line) in pressure-fixed mouse aortas very closely approximates the geometry of the media. Atherosclerotic lesions in these vessels protrude inward from the media into the lumen rather than remodeling outward to preserve the shape and diameter of the lumen, in contrast with the Glagov theory of remodeling in humans (9).
