Fig. 2.

Measurement of morphological parameters from histology. A: lesion coverage of the wall was defined as the percentage of the vessel circumference with nonzero thickness between the internal elastic lamina (IEL) and the lumen border. B: plaque burden was defined as the percentage of the area inside the IEL occupied by the lesion. C: mean lesion thickness was defined as the mean thickness of the lesion normalized to the mean thickness of the media (37). D: eccentricity was defined as the distance between the centroid of the lumen border and the centroid of the IEL border, normalized to vessel radius.