Fig. 3.

Morphological measures of murine and human plaques. Geometric features of atherosclerotic plaques were measured from histology specimens of lesions from humans and mice. Error bars represent SE. Tukey's honestly significant difference test results are noted for comparisons of brachiocephalic aorta versus the human coronary artery and all descending aortae pooled together versus the human coronary artery. Top left: lesion coverage of the wall. Top right: plaque burden. Bottom left: normalized mean lesion thickness. Bottom right: normalized eccentricity. ApoE^−/− mice, apolipoprotein E-deficient mice; HF diet, high-fat diet; reg, regular.