Table 1.
Metric | Young ApoE−/− Mice Versus Young LDLR−/− Mice | Young ApoE−/− Mice Versus Old ApoE−/− Mice | Young LDLR−/− Mice Versus Old ApoE−/− Mice | Young ApoE−/− Mice Versus Humans | Young LDLR−/− Mice Versus Humans | Old ApoE−/− Mice Versus Humans |
---|---|---|---|---|---|---|
Percentage of wall covered with lesion | 0.29219 | <0.00001 | 0.00010 | 0.00198 | 0.00001 | <0.00001 |
Plaque burden | 0.97702 | 0.14574 | 0.27482 | <0.00001 | <0.00001 | <0.00001 |
Lesion thickness | 0.19357 | 0.99999 | 0.14242 | <0.00001 | <0.00001 | <0.00001 |
Eccentricity | 0.95805 | 0.98027 | 0.77581 | 0.09288 | 0.17335 | 0.04070 |
Percent fibrous | 0.11130 | 0.00146 | <0.00001 | <0.00001 | <0.00001 | 0.00445 |
Percent lipid | 0.00036 | 0.00138 | <0.00001 | 0.08164 | <0.00001 | 0.99999 |
Percent cellular | 0.30812 | 0.99999 | 0.25562 | 0.00044 | 0.01725 | 0.00029 |
Percent calcium | 1.00000 | 0.84934 | 0.83289 | <0.00001 | <0.00001 | 0.00001 |
P values are shown for comparisons among the following groups: young apolipoprotein E-deficient (ApoE−/−) mice, young low-density lipoprotein receptor-deficient (LDLR−/−) mice, old ApoE−/− mice, and humans.