Fig. 2.

Effect of 12(S)-HETE and 12(R)-HETE on relaxations of mouse mesenteric arteries preconstricted with U46619. A and B: representative isometric tension recordings of mouse mesenteric rings. The arteries were preconstricted with U46619 until they reached 50–70% maximum tension. Upon a stable tension, increasing concentrations of 12(S)- or 12(R)-HETE were added. C: relaxation responses to 12(S)-(●) and 12(R)-HETE (▽) presented as %relaxation (as the basal tension representing 100%). EC₅₀ refers to the concentration of test compound that causes 50% of maximum response. Each value represents the mean ± SE; n = 8–12. #P < 0.05 compared with 12(R)-HETE.