Fig. 6.

Effect of 12(S)-HETE and 12(R)-HETE on vascular tone of mouse mesenteric arteries. Concentration-dependent relaxations of 12(S)- (○) and 12(R)-HETE (▼) on arteries preconstricted with phenylephrine (A) or carbocyclic thromboxane A₂ (CTA₂; B). C: responses of 12(S)- (○) and 12(R)-HETE (▼) on basal tension of the arteries. Concentration-dependent contractions to U46619 (D), I-BOP (E), or phenylephrine (F) in the presence of 12(S)-HETE (1 μM, ○) or 12(R)-HETE (1 μM, ▼). Each value represents the mean ± SE; n = 6–12. *P < 0.05 compared with vehicle control (■). #P < 0.05 compared with 12(S)-HETE.