Fig. 7.
Effects of TP receptor agonists on vascular tone of mouse mesenteric arteries. A: constriction responses induced by different TP receptor agonists; I-BOP (●), U46619 (▽), CTA2 (■), PGF2α (◇), and 8-iso PGF2α (▲). B: relaxations induced by 12(S)-HETE in mouse mesenteric arteries preconstricted with I-BOP (●), U46619 (▽), CTA2 (■), PGF2α (◇), and 8-iso PGF2α (▲). C: U46619-induced contractions in the presence of SQ29548 (10 nM ☆ or 100 nM ◆) or vehicle control (X). D: PGF2α-induced contractions in the arteries pretreated with either vehicle (□) or SQ29548 (5 nM, half filled circle). Each value represents the mean ± SE; n = 4–13. $P < 0.05 compared with basal; *P < 0.05 compared with vehicle control.