Table 1.
Baseline hemodynamics: before vs. after bed rest before dextran infusion
| Condition | Pre | Post | P Value | Change % | Interaction P Value |
|---|---|---|---|---|---|
| Exercise (n = 14) | |||||
| Weight, kg | 79 ± 4 | 76 ± 4 | <0.001* | −2.7 ± 0.4 | 0.759 |
| Plasma volume, liter | 3.39 ± 0.17 | 3.23 ± 0.17 | 0.015* | −4.5 ± 1.8 | 0.111 |
| Blood volume, liter | 5.48 ± 0.30 | 5.33 ± 0.31 | 0.154 | −2.5 ± 1.9 | 0.217 |
| MBP, mmHg | 85 ± 2 | 88 ± 11 | 0.195 | 3.4 ± 2.5 | 0.487 |
| Qc, liter | 7.2 ± 0.3 | 6.7 ± 0.3 | 0.087 | −5.6 ± 3.8 | 0.357 |
| SV, ml | 109 ± 6 | 105 ± 8 | 0.357 | −4.1 ± 3.5 | 0.037* |
| TPR, dyn·s·cm−5 | 976 ± 50 | 1,079 ± 59 | 0.029* | 11.5 ± 4.3 | 0.537 |
| PCWP, mmHg | 11.0 ± 0.4 | 9.5 ± 0.5 | 0.002* | −14.0 ± 3.6 | 0.221 |
| RAP, mmHg | 7.8 ± 0.5 | 6.7 ± 0.5 | 0.043* | −11.7 ± 6.5 | 0.368 |
| LVEDV, ml | 127 ± 8 | 120 ± 7 | 0.014* | −4.7 ± 1.9 | 0.021* |
| LV mass, g | 146 ± 9 | 154 ± 11 | 0.046* | 4.6 ± 2.2 | 0.021* |
| Sedentary (n = 7) | |||||
| Weight, kg | 78 ± 6 | 76 ± 5 | 0.036* | −2.4 ± 0.8 | |
| Plasma volume, liter | 3.4 ± 0.2 | 3.1 ± 0.2 | <0.001* | −8.8 ± 0.5 | |
| Blood volume, liter | 5.5 ± 0.3 | 5.2 ± 0.3 | <0.001* | −6.0 ± 0.7 | |
| MBP, mmHg | 85 ± 2 | 85 ± 3 | 0.958 | 0.4 ± 3.5 | |
| Qc, liter | 7.4 ± 0.2 | 6.5 ± 0.4 | 0.038* | −11.5 ± 4.4 | |
| SV, ml | 113 ± 7 | 95 ± 5 | <0.001* | −15.8 ± 2.0 | |
| TPR, dyn·s·cm−5 | 936 ± 38 | 1,081 ± 47 | 0.003* | 15.7 ± 3.3 | |
| PCWP, mmHg | 10.2 ± 0.6 | 7.9 ± 0.4 | 0.003* | −21.5 ± 4.2 | |
| RAP, mmHg | 6.6 ± 0.7 | 5.0 ± 0.3 | 0.019* | −21.0 ± 5.6 | |
| LVEDV, ml | 140 ± 7 | 123 ± 5 | <0.001* | −12.2 ± 1.7 | |
| LV mass, g | 158 ± 6 | 152 ± 6 | 0.064 | −3.8 ± 1.7 | |
Values are means ± SE. Pre, before bed rest; Post, after bed rest; MBP, mean blood pressure; Qc, cardiac output; SV, stroke volume; TPR, total peripheral resistance; PCWP, pulmonary capillary wedge pressure; RAP, right atrial pressure; LVEDV; left ventricular end-diastolic volume, LV mass: left ventricular mass by MRI. Post values were obtained before dextran infusion. Pre vs. Post was compared with paired t-tests, and % changes were compared with unpaired t-test for interaction between groups.
*
P < 0.05.