Effects of antioxidant treatment on carotid baroreceptor activity and baroreflex function in IH-treated rats. A–D: MnTMPyP treatment prevents the effects of IH on carotid baroreceptor activity. E: effect of MnTMPyP on heart rate responses to baroreflex activation in IH-treated rats. F: examples of splanchnic nerve activity (SNA) responses to phenylephrine (PE; 3 μg/kg body wt iv at arrows)-induced increase in blood pressure in control (left), IH (middle)-, and IH + MnTMPyP (right)-treated rats. G: average data (means ± SE) of SNA responses to PE (3 μg/kg body wt iv; control = 100%) in control, IH-, and IH + MnTMPyP-treated rats. Data are means ± SE; n = 6 rats in each group. ABP, arterial blood pressure; Int. SNA, integrated SNA. Signficant difference compared with control: *, **, and *** denote *P < 0.05; **P < 0.01; **P < 0.001. Significant difference compared with IH-treated preparations: #P < 0.05; ##P < 0.01.