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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: J Immunol. 2013 Jul 12;191(4):2009–2017. doi: 10.4049/jimmunol.1301317

Figure 2. Immune complexity of NSCLC in CC10-TAg mice.

Figure 2

(A) H&E staining of lungs from negative littermates (-LM) and CC10-TAg mice showing adenomas and adenocarcinoma (top panel), with representative staining for CD45 (bottom panel). (B) Numbers of CD45+ leukocytes per square millimeter of tissue as assessed by immunohistochemistry. n=5 mice per group. (C) Flow cytometric analysis of immune cell infiltrates in CC10-TAg lungs assessed at various stages of neoplastic development, namely hyperplasia/dysplasia (4 weeks), adenomas (8 weeks) and adenocarcinomas (16 weeks), represented as percentages of total CD45+ leukocytes. (D) CD4+ T cell lung infiltrate as assessed by flow cytometry, shown as a percent of total CD45+ cells. n=5∓8 mice per group. Significant differences are shown relative to negative littermates. *p<0.05; **p<0.01, ***p<0.001.

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