Figure 5.

Intraperitoneal glucose and insulin tolerance tests. (a) Glucose tolerance test. Overnight-starved mice were given an intraperitoneal injection of glucose (1 mg/g body wt). Blood samples were taken at the times indicated from the tail vein of the same animals. Glucose was measured as indicated in Methods. Results are mean ± SEM of 12 transgenic and 12 control mice. (b) Insulin tolerance test. Awake fed control and transgenic mice were injected intraperitoneally with 0.75 IU of a soluble insulin. Blood samples were taken from the tail vein of the same animals at the times indicated, and glucose concentration was determined as indicated in Methods. Results are mean ± SEM of 8 transgenic and 8 control mice. *P < 0.05 vs. control.