Table 1.
Summary of differentially expressed genes
| Responsive Genes |
|||
|---|---|---|---|
| Downregulated | Upregulated | ||
| 100 μM copper | |||
| 4 h | ND | 10 | |
| 8 h | ND | 9 | |
| 12 h | ND | 6 | |
| 24 h | ND | 11 | |
| 200 μM copper | |||
| 4 h | ND | 29 | |
| 8 h | ND | 8 | |
| 12 h | ND | 20 | |
| 24 h | 1 | 19 | |
| 400 μM copper | |||
| 4 h | 6 | 119 | |
| 8 h | 37 | 137 | |
| 12 h | 97 | 200 | |
| 24 h | 113 | 209 | |
| 600 μM copper | |||
| 4 h | 173 | 361 | |
| 8 h | 335 | 384 | |
| 12 h | 732 | 791 | |
| 24 h | 496 | 500 | |
HepG2 cells were exposed to 100, 200, 400, and 600 μM copper for 4, 8, 12 and 24 h. Shown are numbers of responsive genes with a ≥2-fold change in expression with false discovery rate (FDR) P ≤ 0.05. ND, none detected.