Table 4.
Enriched GO categories for K-means clusters
| Cluster 1 |
| Voltage-gated sodium channel activity |
| Alcohol dehydrogenase activity |
| Oxidoreductase activity\acting on the aldehyde or oxo group of donors |
| Aminomethyltransferase activity |
| Carboxylic acid metabolism |
| Steroid biosynthesis |
| Cell cycle arrest |
| Negative regulation of caspase activity |
| Estrogen metabolism |
| Glucuronosyltransferase activity |
| Xenobiotic metabolism |
| Neurotransmitter uptake |
| Serine-type endopeptidase inhibitor activity |
| Cluster 2 |
| Establishment of chromosome localization |
| G2 phase of the mitotic cell cycle |
| Mitosis |
| Spindle organization and biogenesis |
| Nucleosome assembly |
| Phosphoinositide-mediated signaling |
| Fatty acid β-oxidation |
| Microspike biogenesis |
| Pyrimidine deoxyribonucleotide biosynthesis |
| Racemase and epimerase activity |
| Response to DNA damage stimulus |
| Ribose phosphate diphosphokinase activity |
| Cluster 3 |
| 1-Phosphatidylinositol-4-phosphate 5-kinase activity |
| Chemokine activity |
| Chemotaxis |
| Cyclin-dependent protein kinase inhibitor activity |
| Endosome organization and biosynthesis |
| NAD+ ADP-ribosyltransferase activity |
| Negative regulation of transcription, DNA dependent |
| Regulation of transcription from RNA polymerase II promoter |
| Transcriptional repressor acitivity |
| Response to unfolded protein |
| Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity |
| Transition metal ion binding |
| Ubiquitin cycle |
| Ubiquitin-dependent protein catabolism |
| Ubiquitin-protein ligase activity |
| Cluster 4 |
| Cell adhesion |
| Cluster 5 |
| Transition metal ion binding |
| Cluster 6 |
| cAMP-dependent protein kinase regulator activity |
| Detection of stimulus during sensory perception |
| Histamine receptor activity |
| Regulation of neurotransmitter levels |
| Synaptic transmission\cholinergic |
| Cluster 7 |
| Apical junction assembly |
| Cytoskeletal protein binding |
| Myofibril assembly |
| Establishment and/or maintenance of chromatin architecture |
| Regulation of cell growth |
| Positive regulation of cell proliferation |
| S100β binding |
| Glycerol kinase activity |
| Glycerol-3-phosphate metabolism |
| GTPase activator activity |
| Regulation of GTPase activity |
| IκB kinase/NF-κB cascade |
| PKC inhibitor activity |
| Pyridine nucleotide biosynthesis |
| Cluster 8 |
| Bile acid catabolism |
| Glutathione transferase activity |
| Hemoglobin binding |
| Lipid transporter activity |
| Lipoprotein metabolism |
| Polysaccharide biosynthesis |
| Blood pressure regulation |
| Wound healing |
| Cluster 9 |
| Collagen catabolism |
| Peptidoglycan metabolism |
| IGF binding |
| Regulation of cell growth |
| MAPK phosphatase activity |
| Myeloid cell differentiation |
| Protein dimerization activity |
| Protein folding |
| Response to unfolded protein |
| Cluster 10 |
| Nucleosome assembly |
| Serine family amino acid metabolism |
| Cluster 11 |
| Activation of MAPKKK activity |
| Alkanesulfonate biosynthesis |
| Cysteine metabolism |
| Negative regulation of apoptosis |
| Cell cycle arrest |
| Regulation of cyclin-dependent protein kinase acitivity |
| Cell fate determination |
| Notch binding |
| Cell motility |
| Growth factor activity |
| Chemokine activity |
| Inorganic anion exchanger activity |
| LDL receptor activity |
| Phosphofructokinase activity |
| Protein dimerization activity |
| Protein kinase inhibitor activity |
| Cluster 12 |
| Cell migration |
| Immune response |
| Transmembrane receptor acitivity |
| Potassium ion binding |
| Voltage-gated potassium channel activity |