Table 6.
Significant canonical pathways
| Exposure Time, h |
||||||
|---|---|---|---|---|---|---|
| 4 | 8 | 12 | 24 | |||
| 100 μM copper | ||||||
| IL-10 signaling | ||||||
| IL-2 signaling | ||||||
| EGF signaling | ||||||
| Neurotrophin/TRK signaling | ||||||
| Toll-like receptor signaling | ||||||
| IGF-I signaling | ||||||
| IL-6 signaling | ||||||
| 200 μM copper | ||||||
| IL-10 signaling | IGF-I signaling | IL-10 signaling | IGF-I signaling | |||
| IL-6 signaling | IL-10 signaling | IL-6 signaling | IL-2 signaling | |||
| IL-2 signaling | IL-2 signaling | IL-2 signaling | IL-10 signaling | |||
| EGF signaling | EGF signaling | EGF signaling | EGF signaling | |||
| Neurotrophin/TRK signaling | Neurotrophin/TRK signaling | Neurotrophin/TRK signaling | ||||
| Toll-like receptor signaling | Toll-like receptor signaling | Toll-like receptor signaling | ||||
| Hypoxia signaling in the cardiovascular system | Hypoxia signaling in the cardiovascular system | |||||
| 400 μM copper | ||||||
| IL-10 signaling | Protein ubiquitination pathway | Xenobiotic metabolism signaling | Leukocyte extravasation signaling | |||
| Death receptor signaling | Leukocyte extravasation signaling | IL-10 signaling | IL-10 signaling | |||
| IL-6 signaling | Toll-like receptor signaling | Xenobiotic metabolism signaling | ||||
| Toll-like receptor signaling | ||||||
| IGF-I signaling | ||||||
| Leukocyte extravasation signaling | ||||||
| 600 μM copper | ||||||
| Sonic hedgehog signaling | Protein ubiquitination pathway | Xenobiotic metabolism signaling | Leukocyte extravasation signaling | |||
| Death receptor signaling | Sonic hedgehog signaling | IL-10 signaling | ||||
| IL-6 signaling | Hypoxia signaling in the cardiovascular system | Xenobiotic metabolism signaling | ||||
| IGF-I signaling | ||||||
TRK, tyrosine receptor kinase.