Table 7.
Significant functional networks
| Exposure Time, h |
||||||
|---|---|---|---|---|---|---|
| 4 | 8 | 12 | 24 | |||
| 100 μM copper | ||||||
| Amino acid metabolism | Cancer | Amino acid metabolism | Amino acid metabolism | |||
| Cancer | Cell cycle | Cancer | Cancer | |||
| Carbohydrate metabolism | Cell death | Carbohydrate metabolism | Carbohydrate metabolism | |||
| Cell cycle | Cell morphology | Cell cycle | Cell cycle | |||
| Cell death | Cell signaling | Cell death | Cell death | |||
| Cell morphology | Cell-to-cell signaling and interactions | Cell morphology | Cell morphology | |||
| Cell signaling | Cellular growth and proliferation | Cell signaling | Cell signaling | |||
| Cell-to-cell signaling and interactions | DNA replication, recombination, and repair | Cell-to-cell signaling and interactions | Cellular growth and proliferation | |||
| Lipid metabolism | ||||||
| Cellular growth and proliferation | Free radical scavenging | Cellular growth and proliferation | ||||
| Lipid metabolism | DNA replication, recombination, and repair Free radical scavenging | |||||
| DNA replication, recombination, and repair | ||||||
| Free radical scavenging | Gene expression | |||||
| Gene expression | Immune and lymphatic system development and function Immune response | |||||
| Immune and lymphatic system development and function | ||||||
| Immune response | Lipid metabolism | |||||
| Lipid metabolism | Posttranslational modification | |||||
| Posttranslational modification | ||||||
| 200 μM copper | ||||||
| Amino acid metabolism | Amino acid metabolism | Amino acid metabolism | Amino acid metabolism | |||
| Cancer | Cancer | Cancer | Cancer | |||
| Carbohydrate metabolism | Carbohydrate metabolism | Carbohydrate metabolism | Carbohydrate metabolism | |||
| Cell cycle | Cell cycle | Cell cycle | Cell cycle | |||
| Cell death | Cell death | Cell death | Cell death | |||
| Cell morphology | Cell morphology | Cell morphology | Cell morphology | |||
| Cell signaling | Cell signaling | Cell signaling | Cell signaling | |||
| Cell-to-cell signaling and interactions | Cell-to-cell signaling and interactions | Cell-to-cell signaling and interactions | Cell-to-cell signaling and interactions | |||
| Cellular growth and proliferation | Cellular growth and proliferation | Cellular growth and proliferation | Cellular growth and proliferation | |||
| DNA replication, recombination, and repair Free radical scavenging | DNA replication, recombination, and repair Free radical scavenging | DNA Replication, recombination, and repair Free radical scavenging | ||||
| DNA replication, recombination, and repair | ||||||
| Free radical scavenging | Gene expression | Gene expression | Gene expression | |||
| Gene expression | Immune and lymphatic system development and function Immune response | Immune and lymphatic system development and function Immune response | Immune and lymphatic system development and function Immune response | |||
| Immune and lymphatic system development and function | ||||||
| Immune response | Lipid metabolism | Lipid metabolism | Lipid metabolism | |||
| Lipid metabolism | Posttranslational modification | Posttranslational modification | ||||
| Posttranslational modification | ||||||
| 400 μM copper | ||||||
| Amino acid metabolism | Amino acid metabolism | Amino acid metabolism | Amino acid metabolism | |||
| Carbohydrate metabolism | Carbohydrate metabolism | Carbohydrate metabolism | Carbohydrate metabolism | |||
| Cell cycle | Cell cycle | Cell cycle | Cell cycle | |||
| Cell death | Cell death | Cell death | Cell death | |||
| Cell morphology | Cell morphology | Cell morphology | Cell morphology | |||
| Cell signaling | Cell-to-cell signaling and interactions | Cell signaling | Cell signaling | |||
| Cell-to-cell signaling and interactions | Cell-to-cell signaling and interactions | |||||
| Cell-to-cell signaling and interactions | Cellular development | |||||
| Cellular growth and proliferation | Cellular development | Cellular development | ||||
| Cellular development | DNA replication, recombination, and repair Gene expression | Cellular growth and proliferation | Cellular growth and proliferation | |||
| Cellular growth and proliferation | DNA replication, recombination, and repair | DNA replication, recombination, and repair | ||||
| DNA replication, recombination, and repair | Immune and lymphatic system development and function | Gene expression | Free radical scavenging | |||
| Immune and lymphatic system development and function Immune response | Gene expression Immune and lymphatic system development and function | |||||
| Free radical scavenging | Immune response | |||||
| Gene expression | Lipid metabolism | |||||
| Immune and lymphatic system development and function | ||||||
| Immune response | Posttranslational modification | Lipid metabolism | Immune response | |||
| Lipid metabolism | Protein synthesis | Posttranslational modification | Lipid metabolism | |||
| Protein synthesis | Protein synthesis | Protein synthesis | ||||
| 600 μM copper | ||||||
| Amino acid metabolism | Amino acid metabolism | Amino acid metabolism | Amino acid metabolism | |||
| Carbohydrate metabolism | Carbohydrate metabolism | Carbohydrate metabolism | Carbohydrate metabolism | |||
| Cell cycle | Cell cycle | Cell cycle | Cell cycle | |||
| Cell death | Cell death | Cell death | Cell death | |||
| Cell morphology | Cell morphology | Cell morphology | Cell morphology | |||
| Cell signaling | Cell signaling | Cell signaling | Cell signaling | |||
| Cell-to-cell signaling and interactions | Cell-to-cell signaling and interactions | Cell-to-cell signaling and interactions | Cell-to-cell signaling and interactions | |||
| Cellular development | Cellular development | Cellular development | Cellular development | |||
| Cellular growth and proliferation | Cellular growth and proliferation | Cellular growth and proliferation | Cellular growth and proliferation | |||
| DNA replication, recombination, and repair Free radical scavenging | DNA replication, recombination, and repair Free radical scavenging | DNA replication, recombination, and repair Gene expression | ||||
| DNA replication, recombination, and repair | ||||||
| Gene expression | Gene expression | Gene expression | Immune and lymphatic system development and function Immune response | |||
| Immune and lymphatic system development and function | Immune and lymphatic system development and function | Immune and lymphatic system development and function | ||||
| Immune response | Immune response | Immune response | Lipid metabolism | |||
| Lipid metabolism | Lipid metabolism | Lipid metabolism | Posttranslational modification | |||
| Posttranslational modification | Posttranslational modification | Posttranslational modification | Protein synthesis | |||
| Protein synthesis | Protein synthesis | Protein synthesis | ||||