Table 2.
Genetic covariance (RhoG) among BP phenotypes
| Factor | SBP | DBP | SV | HR | TPR | Renin | Aldo | EP | NE | cGMP | cAMP | ANP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Supine | ||||||||||||
| SBP | 1.00 | 0.84 | 0.22 | 0.07 | 0.81 | 0.25 | 0.17 | 0.30 | 0.47 | 0.14 | 0.34 | nc |
| DBP | 0.84 | 1.00 | 0.38 | 0.09 | 0.93 | 0.06 | 0.30 | 0.21 | 0.39 | 0.03 | 0.35 | nc |
| SV | 0.22 | 0.38 | 1.00 | 0.90 | 0.72 | 0.21 | 0.77 | nc | 0.08 | 0.40 | 0.32 | 0.68 |
| HR | 0.07 | 0.09 | 0.90 | 1.00 | 0.10 | 0.16 | 0.48 | nc | 0.46 | 0.12 | 0.64 | 0.16 |
| TPR | 0.81 | 0.93 | 0.72 | 0.10 | 1.00 | 0.55 | 0.55 | 0.08 | 0.16 | 0.48 | 0.27 | nc |
| Renin | 0.25 | 0.06 | 0.21 | 0.16 | 0.55 | 1.00 | 0.37 | 0.10 | 0.29 | nc | 0.13 | 0.31 |
| Aldo | 0.17 | 0.30 | 0.77 | 0.48 | 0.55 | 0.37 | 1.00 | 0.39 | 0.06 | 0.30 | 0.21 | 0.11 |
| EP | 0.30 | 0.21 | nc | nc | 0.08 | 0.10 | 0.39 | 1.00 | 0.06 | 0.04 | nc | 0.74 |
| NE | 0.47 | 0.39 | 0.08 | 0.46 | 0.16 | 0.29 | 0.06 | 0.06 | 1.00 | 0.27 | 0.04 | nc |
| cGMP | 0.14 | 0.03 | 0.40 | 0.12 | 0.48 | nc | 0.30 | 0.04 | 0.27 | 1.00 | 0.40 | 0.20 |
| cAMP | 0.34 | 0.35 | 0.32 | 0.64 | 0.27 | 0.13 | 0.21 | nc | 0.04 | 0.40 | 1.00 | 0.55 |
| ANP | nc | nc | 0.68 | 0.16 | nc | 0.31 | 0.11 | 0.74 | nc | 0.20 | 0.55 | 1.00 |
| Standing | ||||||||||||
| SBP | 1.00 | 0.88 | 0.31 | 0.01 | 0.60 | 0.38 | nc | 0.06 | 0.14 | 0.03 | 0.78 | 0.13 |
| DBP | 0.88 | 1.00 | 0.13 | 0.23 | 0.63 | 0.15 | nc | 0.07 | 0.59 | 0.06 | 0.72 | 0.06 |
| SV | 0.26 | 0.01 | 1.00 | 0.13 | 0.66 | 0.22 | 0.15 | 0.10 | 0.15 | 0.37 | 0.45 | 0.01 |
| HR | 0.01 | 0.23 | 0.13 | 1.00 | 0.04 | 0.02 | 0.18 | 0.12 | 0.57 | 0.59 | 0.11 | 0.59 |
| TPR | 0.60 | 0.63 | 0.66 | 0.04 | 1.00 | 0.40 | 0.41 | 0.02 | 0.17 | 0.43 | 0.86 | 0.05 |
| Renin | 0.38 | 0.15 | 0.22 | 0.02 | 0.40 | 1.00 | 0.04 | 0.09 | 0.22 | 0.22 | 0.21 | 0.13 |
| Aldo | nc | nc | 0.15 | 0.18 | 0.41 | 0.04 | 1.00 | 0.46 | 0.87 | 0.52 | nc | 0.21 |
| EP | 0.06 | 0.07 | 0.10 | 0.12 | 0.02 | 0.09 | 0.46 | 1.00 | 0.18 | 0.70 | 0.20 | 0.57 |
| NE | 0.14 | 0.59 | 0.15 | 0.57 | 0.17 | 0.22 | 0.87 | 0.18 | 1.00 | 0.15 | 0.25 | 0.04 |
| cGMP | 0.03 | 0.06 | 0.37 | 0.59 | 0.43 | 0.22 | 0.52 | 0.70 | 0.15 | 1.00 | 0.23 | 0.85 |
| cAMP | 0.78 | 0.72 | 0.45 | 0.11 | 0.86 | 0.21 | nc | 0.20 | 0.25 | 0.23 | 1.00 | 0.39 |
| ANP | 0.13 | 0.06 | 0.01 | 0.59 | 0.05 | 0.13 | 0.21 | 0.57 | 0.04 | 0.85 | 0.39 | 1.00 |
Results of bivariate polygenic analysis with SOLAR. Age and sex were covariates. Numbers represent genetic correlations (RhoG) between factors during recumbency or standing. nc, RhoG SE not computable by SOLAR.