Table 5.
Linkage of principal components and factor analysis traits
| Chromosome | Gene | SNP | MAF | Phenotype | P Value | cP Value |
|---|---|---|---|---|---|---|
| Supine | ||||||
| 8 | KCNB2 | rs349337 | 0.05 | FA2 | 4.0 × 10−6 | 4.0 × 10−6 |
| 16 | SCNN1G | rs8045190 | 0.16 | FA3 | 3.0 × 10−7 | 3.0 × 10−7 |
| rs10492791 | 0.25 | FA3 | 7.0 × 10−7 | 7.0 × 10−7 | ||
| Standing | ||||||
| 1 | KCNH1 | rs1934614 | 0.17 | FA2 | 5.0 × 10−7 | 5.0 × 10−7 |
| 2 | SLC8A1 | rs395404 | 0.13 | FA2 | 3.5 × 10−8 | 3.5 × 10−8 |
| 7 | CFTR | rs2237725 | 0.10 | PC1 | 3.0 × 10−6 | 3.0 × 10−6 |
| 9 | IKBKAP | rs10512384 | 0.07 | FA2 | 8.1 × 10−12 | 8.1 × 10−12 |
| FXN | rs953588 | 0.45 | FA2 | 4.1 × 10−6 | 4.1 × 10−6 | |
| 17 | PRKCA | rs10512510 | 0.06 | FA2 | 7.7 × 10−13 | 7.7 × 10−13 |
| rs10512510 | 0.06 | PC1 | 4.2 × 10−6 | 4.2 × 10−6 | ||
| rs172939 | 0.34 | PC3 | 3.0 × 10−7 | 3.0 × 10−7 | ||
| 20 | MMP9 | rs4812989 | 0.05 | FA1 | 4.0 × 10−6 | 4.0 × 10−6 |
Nominal and Bonferroni: (cP) P values (Alpha threshold = 4.46×10−6) for principal components of hemodynamic traits in supine or standing position. PC1, PC2, PC3: principal components explaining the variance among all traits during supine or standing. FA1, FA2, FA3: factors explaining intercorrelations among all traits during recumbency or standing.