Table 1.
Baseline characteristics for patients in training group
| ALI + Sepsis | Sepsis | |
|---|---|---|
| Patients, n | 13 | 20 |
| Sex (%) | ||
| Male | 6 (46%) | 9 (45%) |
| Female | 7 (54%) | 11 (55%) |
| Age, yr | 56.2±4.8 | 58.9±4.0 |
| Race (%) | ||
| White | 11 (84%) | 15 (75%) |
| African American | 1 (8%) | 0 (0%) |
| Unknown | 1 (8%) | 5 (25%) |
| Severity of disease | ||
| Apache II | 20.7±1.5 | 20.7±1.7 |
| Mortality (%) | 5 (38%) | 7 (35%) |
| Site of infection (%) | ||
| Lung | 5 (38%) | 9 (45%) |
| Heart | 2 (10%) | |
| Abdomen | 5 (38%) | 3 (15%) |
| Urinary tract | 1 (5%) | |
| Meninges | 2 (10%) | |
| Other | 3 (24%) | 3 (15%) |
| Comorbidities (%) | ||
| Hypertension | 2 (15%) | 4 (19%) |
| Heart disease | 2 (15%) | 6 (29%) |
| Diabetes | 4 (31%) | 11 (52%) |
| COPD | 4 (19%) | |
| Cancer | 1 (5%) | |
| Liver disease | 2 (15%) | 2 (10%) |
| Renal insufficiency | 4 (19%) | |
| Malnutrition | 2 (15%) | 2 (10%) |
| Substance abuse | 4 (19%) | |
| Immunosuppression | 2 (15%) | 4 (19%) |
| Recent surgery | 2 (15%) | 1 (5%) |
| P:F ratio | 152±29.4 | 191±26.3 |
| Average PEEP | 11.25±1.25 | 6.53±.79 |
| Bilateral infiltrates on chest X-ray | 13 (100%) | 0 (100%) |
| Microbiology | ||
| Gram positive | 6 (46%) | 9 (45%) |
| Gram negative | 3 (23) | 6 (30%) |
| Negative culture | 4 (31%) | 5 (25%) |
| Positive cultures % | ||
| Blood | 6 (46%) | 10 (48%) |
| Sputum | 3 (23%) | |
| Urine | 3 (14%) | |
| BAL | 1 (5%) | |
| CSF | 1 (5%) | |
| Negative cultures (%) | 4 (31%) | 5 (25%) |
| Specialized treatment | ||
| Corticosteroids | 8 (62%) | 13 (65%) |
| Drotecogin-α | 1 (8%) | 4 (20%) |
| Antibiotics | ||
| β-Lactam | 9 (69%) | 10 (50%) |
| Cephalosporin | 5 (38%) | 10 (50%) |
| Aminoglycoside | 3 (15%) | |
| Fluoroquinolone | 4 (31%) | |
| Macrolide | 4 (31%) | 8 (40%) |
| Antifungal | 1 (8%) | 2 (10%) |
| Vancomycin | 9 (69%) | 13 (65%) |
| LV dysfunction by echo (%) | ||
| Yes | 1 (8%) | 6 (30%) |
| No | 12 (92%) | 13 (65%) |
| Unknown | 1 (5%) |
Plus/minus values are means ± SE. ALI, acute lung injury; APACHE, Acute Physiology and Chronic Health Evaluation score; COPD, chronic obstructive pulmonary disease; PEEP, positive end-expiratory pressure; BAL, bronchoalveolar lavage; CSF, cerebrospinal fluid.