. 2012 Jun 12;44(15):754–763. doi: 10.1152/physiolgenomics.00027.2012

Table 3.

Nominally significant associations of polymorphisms with rate of decline of lung function in the LHS cohort

			Genotype Counts		Unadjusted Analysis		Adjusted Analysis^‡
SNP	Gene	Genotype	Nondecliners	Fast Decliners	P Value^*	Permuted P Value^†	Odds Ratio	95% Confidence Interval	P Value
rs9573956	IRG1	AA	6	0	0.0006	0.0009	0.443	0.267–0.735	0.0016
		AG	48	25
		GG	231	237
rs3092794	NCOA3	AA	61	41	0.0351	0.0318	0.683	0.525–0.888	0.0044
		AG	153	130
		GG	71	89
rs6125042	NCOA3	CC	5	8	0.0517	0.0555	1.646	1.143–2.371	0.0074
		TC	53	68
		TT	227	184
rs9565305	IRG1	GG	5	0	0.0043	0.0030	0.522	0.325–0.840	0.0074
		TG	51	31
		TT	229	231
rs11085735	KEAP1	GG	261	223	0.0292	0.0496	2.043	1.206–3.461	0.0079
		TG	23	34
		TT	1	5
rs17708487	BACH2	AA	168	134	0.1657	0.1628	1.478	1.102–1.983	0.0091
		AG	99	108
		GG	16	19
rs8176199	BRCA1	AA	170	140	0.0348	0.0342	1.513	1.097–2.088	0.0116
		AC	82	93
		CC	8	17
rs634534	FOSL1	AA	59	45	0.0861	0.0872	0.733	0.567–0.948	0.0179
		AG	145	121
		GG	79	96
rs16882297	BACH2	CC	262	226	0.0369	0.0345	1.941	1.105–3.407	0.0209
		GC	23	34
		GG	0	2
rs5758223	EP300	AA	160	129	0.0648	0.0610	1.366	1.039–1.796	0.0255
		AG	107	103
		GG	18	30
rs4722029	GNA12	CC	10	14	0.0526	0.0555	1.427	1.043–1.952	0.0262
		TC	77	92
		TT	197	156
rs20552	EP300	AA	123	104	0.0634	0.0633	1.333	1.033–1.720	0.0273
		TA	130	110
		TT	32	48
rs1915919	PCAF	CC	114	77	0.0281	0.0295	1.338	1.030–1.739	0.0292
		TC	133	139
		TT	38	46
rs176713	BACH2	AA	230	192	0.1166	0.1238	1.549	1.042–2.303	0.0305
		AG	53	67
		GG	2	3
rs6808352	PCAF	GG	17	33	0.0242	0.0221	1.358	1.029–1.792	0.0307
		TG	129	114
		TT	139	115
rs427967	NCOA3	CC	174	184	0.0777	0.0819	0.700	0.504–0.971	0.0325
		TC	100	70
		TT	11	8
rs9344981	BACH2	CC	108	83	0.1763	0.1780	1.332	1.023–1.736	0.0334
		TC	140	133
		TT	37	46
rs4951627	ATF3	CC	16	7	0.0544	0.0552	0.708	0.514–0.976	0.0349
		CG	92	70
		GG	177	185
rs10183914	NFE2L2	CC	115	121	0.3724	0.3840	0.749	0.571–0.982	0.0365
		TC	134	113
		TT	36	28
rs9565304	IRG1	AA	215	215	0.0608	0.0625	0.656	0.442–0.974	0.0365
		AG	62	45
		GG	8	2
rs3846991	GNA12	CC	31	37	0.1178	0.1220	1.315	1.013–1.707	0.0394
		CG	120	124
		GG	134	101
rs831172	IRG1	AA	93	99	0.2760	0.2760	0.760	0.584–0.990	0.0422
		AG	141	126
		GG	51	36
rs2143491	NCOA3	CC	115	127	0.1535	0.1520	0.758	0.579–0.993	0.0444
		TC	134	110
		TT	35	25

The odds ratios are for a rapid rate of decline and the reference is the wild-type homozygote genotype. SNP, single nucleotide polymorphism.

Likelihood ratio χ²-test.

^†

P value using 10,000 random permutations.

^‡

Association under an additive genetic model adjusted for age, sex, pack-years of smoking, and recruitment center.