. 2012 Jun 12;44(15):754–763. doi: 10.1152/physiolgenomics.00027.2012

Table 4.

Associations of polymorphisms with rate of decline of lung function in the Vlagtwedde-Vlaardingen cohort, under an additive genetic model adjusted for sex and pack-years of smoking

			Genotype Counts
SNP	Gene	Genotype	Nondecliners	Fast Decliners	Odds Ratio	95% Confidence Interval	P Value
rs9573956	IRG1	AA	0	1	1.279	0.772–2.120	0.340
		AG	35	32
		GG	260	196
rs3092794	NCOA3	AA	59	45	0.915	0.703–1.190	0.507
		AG	152	112
		GG	67	64
rs6125042	NCOA3	CC	4	2	0.978	0.603–1.584	0.927
		TC	40	25
		TT	176	120
rs9565305	IRG1	GG	0	1	1.188	0.723–1.952	0.496
		TG	38	32
		TT	251	191
rs11085735	KEAP1	GG	266	205	1.133	0.642–1.999	0.667
		TG	27	24
		TT	1	0
rs17708487	BACH2	AA	168	116	1.198	0.903–1.591	0.211
		AG	102	94
		GG	19	16
rs8176199	BRCA1	AA	172	126	1.137	0.856–1.511	0.375
		AC	98	82
		CC	17	18
rs634534	FOSL1	AA	45	49	1.374	1.060–1.781	0.016
		AG	147	119
		GG	102	57
rs16882297	BACH2	CC	261	211	0.629	0.331–1.198	0.158
		GC	28	15
		GG	1	0
rs5758223	EP300	AA	157	120	0.850	0.638–1.132	0.266
		AG	99	88
		GG	29	9
rs4722029	GNA12	CC	12	24	1.206	0.908–1.603	0.196
		TC	106	67
		TT	172	131
rs20552	EP300	AA	126	90	0.965	0.744–1.252	0.789
		TA	126	114
		TT	43	23
rs1915919	PCAF	CC	109	83	0.952	0.736–1.231	0.706
		TC	127	108
		TT	47	31
rs176713	BACH2	AA	224	156	1.367	0.950–1.967	0.092
		AG	64	65
		GG	4	4
rs6808352	PCAF	GG	31	18	0.920	0.700–1.209	0.549
		TG	115	96
		TT	138	109
rs427967	NCOA3	CC	187	160	0.830	0.586–1.173	0.291
		TC	84	57
		TT	8	5
rs9344981	BACH2	CC	91	70	0.970	0.758–1.241	0.806
		TC	132	111
		TT	68	45
rs4951627	ATF3	CC	14	9	1.093	0.800–1.492	0.577
		CG	80	72
		GG	194	141
rs13001694^†	NFE2L2	CC	95	82	0.878	0.678–1.137	0.323
		TC	145	116
		TT	52	32
rs9565304	IRG1	AA	241	178	1.253	0.819–1.918	0.298
		AG	48	47
		GG	2	1
rs3846991	GNA12	CC	32	42	1.221	0.943–1.582	0.130
		CG	142	98
		GG	114	84
rs831172	IRG1	AA	106	78	1.135	0.873–1.476	0.346
		AG	146	114
		GG	37	37
rs2143491	NCOA3	CC	100	88	0.978	0.747–1.280	0.871
		TC	156	106
		TT	35	31

The odds ratios are for a rapid rate of decline, and the reference is the wild-type homozygote genotype.

^†

In almost complete linkage disequilibrium (r² = 0.964) with SNP rs10183914 according to HapMap.