Table 4.
Top 15 most up- or downregulated genes in PCK and FHH.Pkhd1 compared with their respective controls
| Gene Symbol | Gene Name | Fold Change |
|---|---|---|
| PCK vs. SD (up-) | ||
| Fam111A | family with sequence similarity 111, member A | 32.08 |
| Serpina3 | serpin peptidase inhibitor, clade A , member 3 | 27.44 |
| Havcr1(Kim1) | hepatitis A virus cellular receptor 1 | 8.90 |
| Akr1b15 | aldo-keto reductase family 1, member B15 | 5.54 |
| Dusp15 | dual specificity phosphatase 15 | 4.96 |
| Cps1 | carbamoyl-phosphate synthase 1, mitochondrial | 4.83 |
| Col17A1 | collagen, type XVII, alpha 1 | 4.15 |
| Slc7a12 | solute carrier family 7, member 12 | 3.64 |
| Parm1 | peptidase domain containing associated with muscle regeneration 1 | 3.63 |
| Snap91 | synaptosomal-associated protein, 91 kDa homolog | 3.61 |
| Lypd2 | LY6/PLAUR domain containing 2 | 3.32 |
| Lamc2 | laminin, gamma 2 | 3.22 |
| Pard6 g | par-6 partitioning defective 6 homolog gamma | 3.14 |
| Hrg | histidine-rich glycoprotein | 3.06 |
| Mal2 | mal, T-cell differentiation protein 2 | 3.03 |
| PCK vs. SD (down-) | ||
| LOC690251 | Sumo1/sentrin/SMT3 specific peptidase 5 | −7.70 |
| Enpp6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | −6.65 |
| Ephx2 | epoxide hydrolase 2, cytoplasmic | −6.05 |
| Hla-dqa1 | major histocompatibility complex, class II, DQ alpha 1 | −6.00 |
| Mx1 | myxovirus resistance 1, interferon-inducible protein p78 | −5.57 |
| Resp18 | regulated endocrine-specific protein 18 homolog | −5.01 |
| Rt1-t24-3 | RT1 class I, locus T24, gene 3 | −4.15 |
| Eml1 | echinoderm microtubule associated protein like 1 | −3.86 |
| Ahsp | alpha hemoglobin stabilizing protein | −3.76 |
| Ugt2b15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | −3.64 |
| Plekhh1 | pleckstrin homology domain containing, family H member 1 | −3.57 |
| Pcdh9 | protocadherin 9 | −3.50 |
| Gc | group-specific component | −3.27 |
| Slco1a1 | solute carrier organic anion transporter family, member 1a1 | −3.14 |
| Alox15 | arachidonate 15-lipoxygenase | −3.05 |
| FHH.Pkhd1 vs. FHH (up-) | ||
| Ddx6 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 | 7.11 |
| Cd2ap | CD2-associated protein | 4.84 |
| Cyp11B2 | cytochrome P450, family 11, subfamily B, polypeptide 2 | 4.57 |
| Akr1b7 | aldo-keto reductase family 1, member B7 | 3.51 |
| Cdkn1B | cyclin-dependent kinase inhibitor 1B | 3.35 |
| Scd | stearoyl-CoA desaturase | 2.89 |
| Bptf | bromodomain PHD finger transcription factor | 2.69 |
| Rab1b | RAB1B, member RAS oncogene family | 2.44 |
| S100a9 | S100 calcium binding protein A9 | 2.36 |
| Sfrp1 | secreted frizzled-related protein 1 | 2.33 |
| Znf609 | zinc finger protein 609 | 2.29 |
| LOC100363366 | amyloid beta (A4) precursor-like protein 2-like | 2.24 |
| Lsm14B | LSM14B, SCD6 homolog B | 2.21 |
| Cbx1 | chromobox homolog 1 | 2.15 |
| Dnajc7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | 2.14 |
| FHH.Pkhd1 vs. FHH (down-) | ||
| Slco1a1 | solute carrier organic anion transporter family, member 1a1 | −18.26 |
| Dhrs7 | similar to dehydrogenase/reductase member 7 | −10.75 |
| Ugt2b15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | −10.12 |
| Cyp4a22 | cytochrome P450, family 4, subfamily A, polypeptide 22 | −9.70 |
| Snca | synuclein, alpha | −9.33 |
| Akr1c12 | aldo-keto reductase family 1, member C12 | −7.64 |
| Akr1c4 | aldo-keto reductase family 1, member C4 | −6.22 |
| Tff3 | trefoil factor 3 | −5.05 |
| Slc7a12 | solute carrier family 7, member 12 | −3.77 |
| RGD1564865 | similar to 20-alpha-hydroxysteroid dehydrogenase | −3.73 |
| Pzp | pregnancy-zone protein | −3.60 |
| Cyp2d9 | cytochrome P450, family 2, subfamily d, polypeptide 9 | −3.29 |
| Apcs | amyloid P component, serum | −3.01 |
| Trpv1 | transient receptor potential cation channel, subfamily V, member 1 | −2.91 |
| Pcdh9 | protocadherin 9 | −2.80 |