Table 5.
Genes found to be up- or downregulated in the same direction in PCK and FHH.Pkhd1 kidneys at 30 days of age
| Fold Change |
|||
|---|---|---|---|
| Gene Symbol | Gene Name | FHH.Pkhd1 vs. FHH | PCK vs. SD |
| Common upregulated genes | |||
| Cps1 | carbamoyl-phosphate synthase 1, mitochondrial | 1.45 | 4.83 |
| Mttp | microsomal triglyceride transfer protein | 2.08 | 2.63 |
| Kng1 | kininogen 1 | 1.47 | 2.53 |
| Snx10 | sorting nexin 10 | 1.44 | 2.28 |
| Fgb | fibrinogen beta chain | 1.61 | 1.98 |
| Klf5 | Kruppel-like factor 5 | 1.47 | 1.75 |
| Slc22A13 | solute carrier family 22, member 13 | 1.41 | 1.63 |
| Gabrp | gamma-aminobutyric acid A receptor, pi | 1.46 | 1.49 |
| Rab1b | RAB1B, member RAS oncogene family | 2.44 | 1.45 |
| S100A9 | S100 calcium binding protein A9 | 2.36 | 1.45 |
| Igfbp5 | insulin-like growth factor binding protein 5 | 1.44 | 1.44 |
| LOC100302372 | hypothetical protein LOC100302372 | 1.82 | 1.43 |
| Scnn1A | sodium channel, nonvoltage-gated 1 alpha | 1.81 | 1.41 |
| Common downregulated genes | |||
| Resp18 | regulated endocrine-specific protein 18 homolog | −1.50 | −5.01 |
| Ugt2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | −10.12 | −3.64 |
| Pcdh9 | protocadherin 9 | −2.80 | −3.50 |
| Slco1a1 | solute carrier organic anion transporter family, member 1a1 | −18.26 | −3.14 |
| Areg | amphiregulin | −1.48 | −2.42 |
| Cyp2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 | −1.46 | −2.22 |
| P2RY1 | purinergic receptor P2Y, G-protein coupled, 1 | −1.70 | −2.12 |
| Akr1C4 | aldo-keto reductase family 1, member C4 | −6.22 | −2.07 |
| Mmp9 | matrix metallopeptidase 9 | −1.42 | −1.81 |
| Akr1c12 | aldo-keto reductase family 1, member C12 | −7.64 | −1.77 |
| Dhrs7 | similar to dehydrogenase/reductase member 7 | −10.75 | −1.76 |
| TrpV1 | transient receptor potential cation channel, subfamily V, member 1 | −2.91 | −1.74 |
| Col9A1 | collagen, type IX, alpha 1 | −1.96 | −1.64 |
| Bhlhe41 | basic helix-loop-helix family, member e41 | −1.79 | −1.63 |
| Ttc21B | tetratricopeptide repeat domain 21B | −1.58 | −1.61 |
| Ganc | glucosidase, alpha; neutral C | −1.50 | −1.58 |
| Tnrrsf11B | tumor necrosis factor receptor superfamily, member 11b | −1.51 | −1.58 |
| Igh-2 | immunoglobulin heavy chain 2 | −1.79 | −1.56 |
| Tff3 | trefoil factor 3 | −5.05 | −1.54 |
| LOC100361122 | SRY-box containing gene 9 | −1.44 | −1.51 |
| Snca | synuclein, alpha | −9.33 | −1.51 |
| RGD1562717 | similar to ABI gene family, member 3 binding protein | −1.43 | −1.48 |
| Fgf13 | fibroblast growth factor 13 | −1.46 | −1.45 |
| C1QL3 | complement component 1, q subcomponent-like 3 | −1.41 | −1.43 |
| Igtp | interferon gamma induced GTPase | −1.57 | −1.42 |
| Ccrn4L | CCR4 carbon catabolite repression 4-like | −1.58 | −1.40 |
This list includes genes that are differentially expressed by >1.4, or <−1.4-fold in both FHH.Pkhd1 and PCK compared to their respective controls.