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. Author manuscript; available in PMC: 2013 Sep 16.
Published in final edited form as: Front Biosci (Elite Ed). 2012 Jan 1;4:2253–2268. doi: 10.2741/540

Table 1.

SOCE dependent processes in cells of the immune system and immune responses in vivo

Cell Type SOCE
induced by		 Cellular immune functions in vitro Immune responses in vivo References
CD4+ T cells TCR/CD3, chemokine
receptors		 Proliferation:

  • Human T cells stimulated with anti-CD3, antigen or mitogen

  • Mouse CD4+ T cells (impaired in STIM1/STIM2-deficient T cells only)

  • Mouse Th17 cells stimulated with anti-CD3

  • Mouse B cells stimulated with anti-IgM (but not LPS)


Cytokine production:

  • IFN gamma in Th1 cells

  • IL-4, IL-10 in Th2 cells

  • IL-17A, IL-17F, IL-22 in Th17 cells

 Rejection of MHC class I/II mismatched skin allografts
Graft vs host disease
Contact hypersensitivity (Th2 cells)
Autoimmune inflammation:

  • Inflammatory bowel disease following transfer of naive CD4+ T cells (Th1, Th17 cells)

  • Experimental autoimmune encephalomyelitis (Th17 cells)

 5, 11, 16, 29, 33–39, 42, 43, 46
CD4+Foxp3+ Regulatory T cells (Treg) TCR/CD3 Intrathymic development of Treg cells
Suppression of T cell proliferation (STIM1/2-deficient Treg only)		 Myelo-lymphoproliferation and autoimmunity (in Stim1fl/flStim2fl/fl Cd4-Cre mice) 16
CD8+ T cells TCR/CD3 Target cell lysis
Degranulation
IFN gamma, TNF alpha production		 Rejection of MHC class I/II mismatched skin allografts 16, 34–36, 38, 39, 42, 60, 61
NK cells CD16 Target cell lysis
Degranulation
IFN gamma and TNF alpha production		 60–64
B cells BCR Anti-IgM-induced proliferation
IL-10 production		 Regulatory B cell function (IL-10 dependent control of EAE) 29, 35, 38, 42, 62, 63, 66
Dendritic cells TLR4, purinergic receptors DC maturation (CD80, CD86, MHC class II expression)
TNF alpha production
Chemotaxic migration (to CCL21)		 73–75
Mast cells Fc epsilon receptor I Release of secretory granules containing serotonin, histamine, beta-hexosaminidase LTC4 synthesis
IL-6, IL-13 and TNF alpha production		 Fc epsilon receptor I-dependent passive cutaneous anaphylaxis 37, 39, 79
Macrophages Fc gamma receptor II, IIIa Phagocytosis of opsonized mouse red blood cells, platelets
MIP-2, TNF alpha production
C5a production		 Autoimmune hemolytic anemia, thrombocytopenia
Immune complex-mediated
pneumonitis		 80
Neutrophils Fc gamma receptor, fMLP receptor Fc gamma receptor-induced phagosomal ROS production
beta 2 integrin-mediated cellular arrest		 29, 35, 42, 89–91, 98

Only those physiological stimuli, effector functions and immune responses are listed for which the involvement of ORAI and STIM proteins has been directly shown.

Abbreviations: BCR, B cell receptor; LTC4, leukotriene C4; TCR, T cell receptor; Th, T helper; TLR, toll-like receptor.