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. Author manuscript; available in PMC: 2013 Sep 16.
Published in final edited form as: Adv Healthc Mater. 2012 Jul 9;1(5):661–668. doi: 10.1002/adhm.201200009

Figure 6.

Figure 6

Theoretical understanding of local cell release in microchannels and comparison to experimental results. A) Schematic for 2D computational modeling of fluid flow and heat transfer inside a microchannel. Thermoelectric module was placed onto locations: x1 = 1 mm for zone 1, and x1 = 6 mm for zone 2. Top surface was 3.5 mm thick polymethyl-methacrylate (PMMA) and bottom surface was 0.65 mm thick polystyrene. To model heat loss from top and bottom surfaces, thermal conductivity of PMMA was set as, k = 0.19 W/m.K, and thermal conductivity of polystyrene was set as, k = 0.08 W/m.K. Channel height is H = 80 μm, and length is L = 25 mm. BC stands for boundary condition. Width of inlet flow was w2 = 250 μm, and width of thermoelectric module was w1 = 4.3 mm. Steady-state surface temperature (°C) distribution as a function of channel location (mm) were plotted in the presence of thermoelectric module at: B) x1 = 1 mm (zone 1), and C) x1 = 6 mm (zone 2). Results from local release experiments were compared to the results from computational model for (D) zone 1, and E) zone 2.