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. Author manuscript; available in PMC: 2013 Sep 16.
Published in final edited form as: Nat Med. 2013 Apr 14;19(5):619–625. doi: 10.1038/nm.3175

Figure 1.

Figure 1

Classification of colorectal tumors and cell lines into subtypes. (a,b) Heatmaps showing CRC subtypes in tumors (from two merged core data sets: GSE13294 and GSE14333) defined by CRCassigner-786 (a) and CRCassigner-30 gene signatures (b). (c) Immunohistochemistry assays of patient CRC samples using candidate CRC subtype-specific markers (four from the CRCassigner-7) to assign subtypes. For immunohistochemistry, each subtype-specific marker was scored +, ++ or +++ for weak, moderate or strong intensity of staining, respectively; see Supplementary Methods and Supplementary Table 1d for more information. Scale bar represents 100 µm. (d) Heatmap showing CRC tumor subtypes from the core tumor data sets described in a and b merged with cancer cell line data19,20. (e) Differential DFS amongst the CRC subtypes from untreated patients from the GSE14333 data set plotted as Kaplan-Meier survival curves. (f) Heatmap depicting known MSI or MSS status for each of the colorectal tumor subtype samples from the data set GSE13294. CFTR, cystic fibrosis transmembrane conductance regulator; MUC2, mucin 2; TA, transit amplifying; TFF3, trefoil factor 3; ZEB1, zing finger E-box–binding homeobox-1.