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. 2013 Sep 16;8(9):e74083. doi: 10.1371/journal.pone.0074083

Figure 5. BMP7 decreases obesity and attenuates liver lipid accumulation, dyslipidemia and hyperglycemia in diet-induced obese mice.

Figure 5

8-week-old male C57Bl/6J mice were fed a high-fat diet (45% fat) for 12 weeks and then treated for 4 weeks with BMP7 (100 µg/kg/day) or saline via a subcutaneous osmotic minipump at an environmental temperature of 21°C while feeding a high-fat diet (A) Body weight development (gram) (B) Total fat mass as measured via DEXA-scan (expressed as percentage of body weight) (C) Energy expenditure measured during 5 consecutive days in the fourth week of treatment via fully automatic metabolic cages (D) Liver content of triglycerides (TG), total cholesterol (TC) and phospholipids (PL) (E) Plasma triglyceride (TG) and total cholesterol (TC) levels. (F) Plasma glucose levels. Values are means+SEM (n = 9). *P<0.05, **P<0.01 compared to the control group.