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. 2013 Sep 16;8(9):e74362. doi: 10.1371/journal.pone.0074362

Figure 2. Sex-specific association between rs17782313 and gray matter volume (GMV).

Figure 2

Sex-specific effects of genotype at rs17782313 on GMV in the right amygdala/hippocampus (z-value 3.97, x = 14, y = −6, z = −22) and bilateral medial orbitofrontal cortex (OFC; left OFC: z-value 3.95, x = −12, y = 24, z = −22; right OFC: z-value 3.76, x = 12, y = 20, z = −20), adjusted for participant’s BMI, age, global gray and white matter volume (interaction between gender and genotype, voxel-wise threshold p<.005, cluster threshold p<.05, corrected for non-isotropic smoothness, indicated by red color). Female homozygous carriers of the minor allele (CC) had higher values than heterozygous subjects (AC) or non-carriers (AA, voxel-wise threshold p<.001, cluster threshold p<.05, corrected for non-isotropic smoothness). No significant difference was found for men.