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. 2013 Sep 16;8(9):e74138. doi: 10.1371/journal.pone.0074138

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© 2013 Zhang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Whole blood was cultured without LPS or with increasing concentrations of LPS 0.5–10⁴ pg/ml for 6 hrs. LPS suppressed both NOP and PNoc mRNA expression. Data are presented as medians with interquartile ranges. n = 4, Kruskal-Wallis test with subsequent post hoc analysis, *: p<0.05. LPS, lipopolysaccharide; NOP, nociceptin receptor; PNoc, nociceptin precursor.