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. 2000 Mar 15;105(6):711–719. doi: 10.1172/JCI9021

Figure 5.

Figure 5

Dermal xanthomatosis in LDLR-deficient mice transplanted with marrow from ACAT1–/–LDLR–/– mice. Bone marrow was harvested from ACAT1+/+LDLR–/– or ACAT1–/–LDLR–/– mice and transplanted into 15-week-old LDLR–deficient recipients. Sections of skin were analyzed after 10 weeks of high-fat feeding. (a and b) Representative H&E-stained sections of skin viewed at the same magnification (×20). Note the marked thickening of the dermis in the mouse that received ACAT1–/–LDLR–/– marrow. (c and d) Immunostaining for macrophages with MOMA-2 antiserum. Numerous macrophages (arrows) were observed in recipients of ACAT1–/–LDLR–/– marrow. (e and f) Immunostaining for mouse ACAT1 with an ACAT1-specific antiserum. Specific staining for ACAT1 was observed in the dermis only in recipients of ACAT1+/+LDLR–/– marrow.