Figure 7.

Macrophage-poor atherosclerotic lesions in ACAT1-deficient mice. Representative MOMA-2 immunostained aortic sections from ACAT1^+/+LDLR^–/– (a) and ACAT1^–/–LDLR^–/– (b) mice fed an atherogenic diet for 2 months and from ACAT^+/+ApoE^–/– (c) and ACAT^–/–ApoE^–/– (d and e) mice fed a Western diet for 3 months. Note the reduction in MOMA-2 staining in the more advanced lesions in ACAT1^–/–LDLR^–/– mice (b) and ACAT1^–/–ApoE^–/– mice (d). Staining was less reduced in the early, fatty-streak lesions of ACAT1^–/–ApoE^–/– mice (e).