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. 2010 Jun 2;104(2):896–901. doi: 10.1152/jn.00414.2010

Fig. 4.

Fig. 4.

The hemichannel blocker carbenoxolone (CBX) blocked ATP release from type II cells. A, left: a representative response to cyclohexamide (Chx 500 μM). Arrowhead, offset of bath perfusion and onset of taste stimulation; CBX (+), application of 10 μM CBX in both bath and recording electrode solutions; N.D., not detectable. B: ATP release from type II cells in response to Chx was blocked by application of CBX to both bath and recording electrode solutions. ATP release was not affected by application of lower concentrations of CBX (0.01 μM, P = 0.41; 0.1 μM, P = 0.33; 1 μM, P = 0.087; vs. “no blockers” by t-test) or mixtures of GAP26 + GAP27 (500 μM, respectively, P = 0.74; vs. “no blockers” by t-test).