Table 4. Activity of crude extracts from fungal endophytes against Leishmania donovani (causative agent of leishmaniasis) in in vitro assays, organized by fungal family.
Family (Order) | Mean %IG (± SE) | Fungal Genotypes Examined | Highly Active Genotypes | % Highly Active Genotypes | Activity Level |
Nectriaceae (Hypocreales) | 34.9 (7.9) | 7 | 2 | 28.6 | High |
Trichocomaceae (Eurotiales) | 21.9 (5.2) | 16 | 2 | 12.5 | High |
Mycosphaerellaceae (Capnodiales) | 20.4 (5.2) | 15 | 3 | 20 | High |
Amphisphaeriaceae (Xylariales) | 18.8 (7.9) | 7 | 0 | 0 | Moderate |
Xylariaceae (Xylariales) | 17.7 (3.1) | 46 | 6 | 13.1 | Moderate |
Valsaceae (Diaporthales) | 15.8 (3.8) | 31 | 1 | 3.2 | Moderate |
Botryosphaeriaceae (Botryosphaeriales) | 15.5 (7.9) | 7 | 0 | 0 | Moderate |
Phyllachoraceae (Phyllachorales) | 9.5 (5.1) | 17 | 0 | 0 | Low |
Boliniaceae (Boliniales) | 7.9 (9.4) | 5 | 0 | 0 | Low |
Magnaporthaceae (Magnaporthales) | 3.9 (9.4) | 5 | 0 | 0 | Low |
Data indicate mean percent inhibition of growth of parasite cells (mean % IG) and standard error, the number of fungal genotypes examined, the number and percent of those genotypes that are highly active (i.e., ≥50% IG), and a qualitative statement of activity level. Mean % IG varied significantly among activity levels (F2, 153 = 4.45; p = 0.0132).