Table 5. TREM1 canonical pathway.
| identified in study nr: | |
| Akt | 5 |
| anti-TREM1 Ab | |
| CASP1 | |
| Casp1-Casp5 | |
| CASP5 | |
| CCL2 | 8 |
| CCL3 | |
| CCL7 | 8 |
| CD40 | 4;8 |
| CD83 | |
| CD86 | |
| CSF2 | |
| CXCL3 | 2 |
| DEFB4A/DEFB4B | |
| EBOV | |
| ERK1/2 | 5 |
| FCGR2B | 5 |
| Flagellin | |
| GRB2 | |
| ICAM1 | |
| IL10 | |
| IL18 | |
| IL1B | |
| IL6 | |
| IL8 | 7 |
| IRAK1 | |
| ITGA5 | |
| ITGAX | |
| ITGB1 | |
| JAK2 | |
| L-Ala-?-D-Glu-meso-diaminopimelinic acid | |
| LAT2 | |
| lipopolysaccharide | |
| lipoteichoic acid | |
| MARV | |
| MARV GP | |
| MPO | 2;6 |
| MYD88 | 4 |
| N-acetylmuramyl-L-alanyl-D-isoglutamine | |
| NFkB (complex) | |
| NLR | |
| NOD2 | |
| Pam3-Cys | |
| PLC gamma | 5 |
| poly rI:rC-RNA | |
| prostaglandin E2 | |
| resiquimod | |
| SIGIRR | |
| ST2 | |
| STAT3 | |
| STAT5a/b | 4 |
| Tlr | 4;8;3* |
| TLR2 | 4 |
| TLR4 | 4 |
| TNF | |
| TREM1 | |
| TYROBP | 3 |
Genes involved in TREM1 signaling canonical pathway according to Ingenuity Integrated Pathway analysis. Genes identified in our 409 gene total geneset are indicated in the right column. * TLR genes include TLR2,4,5,6,7,8 and were identified by multiple studies, all genes identified count in overlap with pathway count according to Ingenuity