Table 5. TREM1 canonical pathway.
identified in study nr: | |
Akt | 5 |
anti-TREM1 Ab | |
CASP1 | |
Casp1-Casp5 | |
CASP5 | |
CCL2 | 8 |
CCL3 | |
CCL7 | 8 |
CD40 | 4;8 |
CD83 | |
CD86 | |
CSF2 | |
CXCL3 | 2 |
DEFB4A/DEFB4B | |
EBOV | |
ERK1/2 | 5 |
FCGR2B | 5 |
Flagellin | |
GRB2 | |
ICAM1 | |
IL10 | |
IL18 | |
IL1B | |
IL6 | |
IL8 | 7 |
IRAK1 | |
ITGA5 | |
ITGAX | |
ITGB1 | |
JAK2 | |
L-Ala-?-D-Glu-meso-diaminopimelinic acid | |
LAT2 | |
lipopolysaccharide | |
lipoteichoic acid | |
MARV | |
MARV GP | |
MPO | 2;6 |
MYD88 | 4 |
N-acetylmuramyl-L-alanyl-D-isoglutamine | |
NFkB (complex) | |
NLR | |
NOD2 | |
Pam3-Cys | |
PLC gamma | 5 |
poly rI:rC-RNA | |
prostaglandin E2 | |
resiquimod | |
SIGIRR | |
ST2 | |
STAT3 | |
STAT5a/b | 4 |
Tlr | 4;8;3* |
TLR2 | 4 |
TLR4 | 4 |
TNF | |
TREM1 | |
TYROBP | 3 |
Genes involved in TREM1 signaling canonical pathway according to Ingenuity Integrated Pathway analysis. Genes identified in our 409 gene total geneset are indicated in the right column. * TLR genes include TLR2,4,5,6,7,8 and were identified by multiple studies, all genes identified count in overlap with pathway count according to Ingenuity