Table 2. iORFV (D1701) reduces antigen cross-presentation by liver sinus endothelial cells (LSEC) but enhances activation of T-cells.
antigen | LSEC+B3Z+PBS (mock-treated) | LSEC+B3Z+ iORFV | comparison vs. mock-treated LSEC (100%) |
ovalbumin | 1084 pg/ml IL2 | 236 pg/ml IL2 | 22% |
SIINFEKL | 1780 pg/ml IL2 | 3043 pg/ml IL2 | 168% |
Activation of CD8+ T cells (B3Z) was measured by IL-2 secretion.