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(A) In the mock, TIA1 (1) and TIAR (R) are located mainly in the nucleus. In these conditions, the amount of TIA1/R is slightly higher that amount of HuR. The binding of TIA1 and TIAR to their corresponding binding site localized in Fas intron 6 promotes exon 6 inclusion. (B) In 2Apro-expressing Huh7-T7 cells, TIA1 and TIAR are translocated to the cytoplasm. The binding of HuR (H) to its site promotes Fas exon 6 skipping.
