Figure 8. Effect of apocynin on hypoxia-inhibited BK_Ca channel activity in uterine arteries.

Smooth muscle cells were isolated from uterine arteries of near-term pregnant sheep maintained at sea level (control) or exposed to high-altitude hypoxia for 110 days. A. Whole-cell K⁺ currents were recorded in the absence (Ctr) or presence of apocynin (APO, 100 µmol/L). B. BK_Ca currents in the presence of 4-AP (5 mmol/L) were recorded in the absence (Ctr) or presence of apocynin (APO, 100 µmol/L). Data are means ± SEM of 4–8 cells from 4–6 animals of each group. *, P<0.05, versus -apocynin (Ctr).